FRY

Across TCGA cell cohorts, FRY mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRY-associated genes across cancer lineages are CUEDC2, EXOSC9, and ZNF232. Each is linked with FRY in more than 2 cancer types. Because this analysis shows association rather than direction, both FRY-to-partner and partner-to-FRY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by FRY-low versus FRY-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRY→partner) and Y-score (partner→FRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.691	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	EXOSC9 →	+0.619	+2.459	<.001	.003	3	3
LARGE_INTESTINE	ZNF232 →	+0.706	+3.257	<.001	.002	3	3
LARGE_INTESTINE	CENPS →	+0.528	+2.043	.001	.001	3	3
LARGE_INTESTINE	RWDD4 →	+0.336	+1.764	.009	.005	3	3
STOMACH	OR4E1 →	+0.008	+3.624	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

CUEDC2 by FRY expression — LARGE_INTESTINE

Explore this box plot interactively →