FRY-AS1

Across TCGA pan-cancer cohorts, FRY-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FRY-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FRY-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FRY-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where FRY-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRY-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.617	<.001	11	view →
KICH	Female	II,III,IV	−0.954	<.001	10	view →
KIRP	Female	All	−0.631	<.001	9	view →
BRCA	All	All	+0.256	<.001	6	view →
LIHC	Male	All	+0.194	<.001	5	view →
UCEC	All	II,III,IV	−0.150	.043	4	view →
PAAD	Female	All	−0.415	.019	2	view →
STAD	All	All	+0.156	.012	2	view →
THCA	All	All	−0.059	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FRY-AS1–KIRC

Open the KIRC breakdown →