FRS2

Across TCGA patient cohorts, FRS2 mutation is significantly associated with the RNA expression of many other genes, with 3,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRS2-associated genes across cancer lineages are MIR98, RNA5SP412, and RNU1-31P. Each is linked with FRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRS2-to-partner and partner-to-FRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR98 grouped by FRS2-low versus FRS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS2→partner) and Y-score (partner→FRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR98 →	+0.187	+1.863	.002	.008	3	2
UCEC	RNA5SP412 →	+0.471	+1.815	<.001	.002	3	2
CESC	RNU1-31P →	+0.454	+4.669	<.001	.007	3	2
CESC	GAGE12H →	+0.394	+5.837	<.001	.001	3	2
UCEC	RNU6-918P →	+0.244	+2.157	<.001	.006	3	2
UCEC	RNA5SP415 →	+0.361	+2.096	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,450 associations by consensus.

MIR98 by FRS2 expression — UCEC

Explore this box plot interactively →