FRRS1L

Across TCGA cell cohorts, FRRS1L mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FRRS1L-associated genes across cancer lineages are VN1R4, IL3, and PRAMEF10. Each is linked with FRRS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both FRRS1L-to-partner and partner-to-FRRS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by FRRS1L-low versus FRRS1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRRS1L→partner) and Y-score (partner→FRRS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VN1R4 by FRRS1L expression — CNS

Explore this box plot interactively →