FRMPD2B

Across TCGA patient cohorts, FRMPD2B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMPD2B-associated genes across cancer lineages are Caspase-8, EGFR_pY1173, and FoxM1. Each is linked with FRMPD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMPD2B-to-partner and partner-to-FRMPD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by FRMPD2B-low versus FRMPD2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMPD2B→partner) and Y-score (partner→FRMPD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.229	-3.558	.037	.002	3	2
UCEC	EGFR_pY1173 →	+0.079	+1.611	.024	.043	3	1
UCEC	FoxM1 →	+0.307	+2.807	.006	.003	3	1
UCEC	p27_pT198 →	+0.168	+2.115	<.001	.019	3	1
UCEC	PCNA →	+0.381	+2.807	<.001	.003	3	1
UCEC	Rab11 →	-0.139	-2.115	.028	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-8 by FRMPD2B expression — UCEC

Explore this box plot interactively →