FRMPD2

Across TCGA patient cohorts, FRMPD2 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMPD2-associated genes across cancer lineages are Cyclin-E2, MIG-6, and STAT3_pY705. Each is linked with FRMPD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FRMPD2-to-partner and partner-to-FRMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FRMPD2-low versus FRMPD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMPD2→partner) and Y-score (partner→FRMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.151	+1.594	.001	.005	3	5
COAD	MIG-6 →	+0.114	+3.182	.010	.009	3	4
UCEC	STAT3_pY705 →	-0.274	-1.054	<.001	.043	3	4
UCEC	Caspase-7-cleavedD198 →	+0.510	+1.671	.002	.003	3	4
COAD	ASNS →	+0.560	+2.330	.001	.020	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.277	-1.137	.030	.037	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-E2 by FRMPD2 expression — UCEC

Explore this box plot interactively →