FRMPD2

Across TCGA pan-cancer cohorts, FRMPD2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FRMPD2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FRMPD2 RNA is repressed in tumor relative to normal tissue. In most cancer types FRMPD2 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, THCA, and BRCA are the cancer types where FRMPD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRMPD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.567	<.001	6	view →
THCA	Female	All	+0.454	<.001	6	view →
BRCA	Female	II,III,IV	−0.363	<.001	6	view →
LUAD	All	All	−0.308	.003	4	view →
LIHC	All	All	+0.026	.009	4	view →
CHOL	Male	All	+0.203	.008	2	view →
KIRC	Male	III,IV	−0.134	.022	2	view →
COAD	All	All	+0.047	.016	2	view →
ESCA	All	All	−0.062	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FRMPD2–LUSC

Open the LUSC breakdown →