FRMPD2

Across TCGA cell cohorts, FRMPD2 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMPD2-associated genes across cancer lineages are RNF122, FOLR2, and MEIKIN. Each is linked with FRMPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMPD2-to-partner and partner-to-FRMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF122 grouped by FRMPD2-low versus FRMPD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMPD2→partner) and Y-score (partner→FRMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNF122 →	+0.542	+3.502	.009	.001	3	2
LIVER	FOLR2 →	+0.031	+3.977	<.001	.006	3	1
CNS	MEIKIN →	+0.069	+4.321	<.001	.009	3	1
OVARY	DMRTC1B →	+0.213	+3.862	<.001	.005	3	1
OVARY	OR2T4 →	+0.020	+4.222	<.001	.006	3	1
LARGE_INTESTINE	FAH →	-0.873	-3.278	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

RNF122 by FRMPD2 expression — SKIN

Explore this box plot interactively →