FRMD8

Across TCGA patient cohorts, FRMD8 mutation is significantly associated with the RNA expression of many other genes, with 2,192 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD8-associated genes across cancer lineages are BNIP3P35, OR8B6P, and RNA5SP164. Each is linked with FRMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD8-to-partner and partner-to-FRMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P35 grouped by FRMD8-low versus FRMD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD8→partner) and Y-score (partner→FRMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P35 →	+0.119	+2.384	.003	.002	3	2
SKCM	OR8B6P →	+0.053	+4.594	<.001	.008	3	2
UCEC	RNA5SP164 →	+0.101	+4.060	<.001	.006	3	2
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	1
COAD	RNU6-533P →	+0.571	+7.741	<.001	.009	3	1
UCEC	EIF2S2P7 →	+0.046	+2.298	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,192 associations by consensus.

BNIP3P35 by FRMD8 expression — UCEC

Explore this box plot interactively →