FRMD8

Across TCGA cell cohorts, FRMD8 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FRMD8-associated genes across cancer lineages are USP17L18, OR2H1, and ACSM6. Each is linked with FRMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD8-to-partner and partner-to-FRMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L18 grouped by FRMD8-low versus FRMD8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD8→partner) and Y-score (partner→FRMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP17L18 →	+0.006	+4.887	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BREAST	IL9 →	+0.053	+5.781	<.001	.001	3	1
BLOOD_Leukemia	SLC32A1 →	+0.699	+3.901	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

USP17L18 by FRMD8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →