FRMD6

Across TCGA patient cohorts, FRMD6 mutation is significantly associated with the RNA expression of many other genes, with 2,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD6-associated genes across cancer lineages are RNU2-27P, HSPD1P12, and OR2A5. Each is linked with FRMD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRMD6-to-partner and partner-to-FRMD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-27P grouped by FRMD6-low versus FRMD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD6→partner) and Y-score (partner→FRMD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-27P →	+0.683	+2.369	<.001	<.001	3	3
LUAD	HSPD1P12 →	+0.108	+2.733	.002	.007	3	2
SARC	OR2A5 →	+0.057	+5.111	.001	.008	3	2
SARC	USP12PY →	+0.051	+5.111	<.001	.008	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
UCEC	CENPM →	+0.613	+1.857	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,585 associations by consensus.

RNU2-27P by FRMD6 expression — UCEC

Explore this box plot interactively →