FRMD6-AS1

Across TCGA pan-cancer cohorts, FRMD6-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FRMD6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FRMD6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FRMD6-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LUSC, THCA, and LIHC are the cancer types where FRMD6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRMD6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.953	<.001	8	view →
THCA	All	All	−0.247	<.001	7	view →
LIHC	All	All	+0.089	<.001	7	view →
BLCA	All	All	+0.464	.002	6	view →
HNSC	All	III,IV	+0.306	.004	6	view →
KIRC	All	II,III,IV	−0.200	.001	5	view →
UCEC	All	All	−0.323	.013	4	view →
LUAD	All	All	+0.290	<.001	4	view →
CHOL	All	All	+0.867	<.001	3	view →
KIRP	All	II,III,IV	+0.396	.025	3	view →
KICH	All	All	−0.331	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FRMD6-AS1–LUSC

Open the LUSC breakdown →