FRMD5

Across TCGA patient cohorts, FRMD5 mutation is significantly associated with the RNA expression of many other genes, with 2,864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD5-associated genes across cancer lineages are MIR493, MIR6817, and ATF4P2. Each is linked with FRMD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both FRMD5-to-partner and partner-to-FRMD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR493 grouped by FRMD5-low versus FRMD5-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD5→partner) and Y-score (partner→FRMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR493 →	+0.383	+8.503	<.001	<.001	3	4
SKCM	MIR6817 →	+0.164	+3.080	<.001	.006	3	3
HNSC	ATF4P2 →	+0.028	+3.440	.002	.009	3	3
UCEC	NIPA1 →	+0.711	+2.136	<.001	<.001	3	3
UCEC	RRM2 →	+0.812	+2.008	<.001	.001	3	3
UCEC	SAR1A →	+0.293	+2.928	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,864 associations by consensus.

MIR493 by FRMD5 expression — LIHC

Explore this box plot interactively →