FRMD4B

Across TCGA cell cohorts, FRMD4B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,536 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FRMD4B-associated GO terms across cancer lineages are Response to indole-3-methanol, Keratinocyte development, and Negative regulation of protein polymerization. Each is linked with FRMD4B in more than 9 cancer types. Because this analysis shows association rather than direction, both FRMD4B-to-partner and partner-to-FRMD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by FRMD4B-low versus FRMD4B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD4B→partner) and Y-score (partner→FRMD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to indole-3-methanol →	+0.197	+2.075	.005	<.001	3	10
BLOOD_Leukemia	Keratinocyte development →	-0.734	-1.563	.005	.006	3	9
PANCREAS	Negative regulation of protein polymerization →	+0.100	+1.085	<.001	<.001	3	8
URINARY_TRACT	Regulation of membrane depolarization during action potential →	+0.141	+1.867	.002	.001	3	8
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.187	+1.641	.003	.005	3	8
LIVER	Regulation of syncytium formation by plasma membrane fusion →	+0.057	+2.061	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

Response to indole-3-methanol by FRMD4B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →