FRMD4B

Across TCGA pan-cancer cohorts, FRMD4B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FRMD4B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FRMD4B RNA is repressed in tumor relative to normal tissue. In most cancer types FRMD4B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and COAD are the cancer types where FRMD4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRMD4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.580	<.001	11	view →
LUAD	Female	III,IV	−1.301	<.001	9	view →
COAD	Female	All	−0.996	<.001	9	view →
KIRC	Female	All	+0.588	<.001	9	view →
THCA	Male	All	−1.077	<.001	7	view →
LUSC	Female	All	−1.272	<.001	6	view →
BRCA	All	All	−0.508	<.001	6	view →
READ	All	All	−1.105	<.001	5	view →
LIHC	All	All	−0.498	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FRMD4B–KICH

Open the KICH breakdown →