FRMD4B

Across TCGA cell cohorts, FRMD4B mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMD4B-associated genes across cancer lineages are CFHR4, OR10A4, and OR1P1. Each is linked with FRMD4B in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD4B-to-partner and partner-to-FRMD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR4 grouped by FRMD4B-low versus FRMD4B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD4B→partner) and Y-score (partner→FRMD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR4 →	+0.095	+3.339	.002	.006	3	2
BLOOD_Leukemia	OR10A4 →	+0.034	+4.177	.005	.001	3	2
BLOOD_Leukemia	OR1P1 →	+0.114	+3.922	<.001	.002	3	2
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	LCE6A →	+0.040	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

CFHR4 by FRMD4B expression — BLOOD_Leukemia

Explore this box plot interactively →