FRMD1

Across TCGA cell cohorts, FRMD1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMD1-associated genes across cancer lineages are FAM205C, KRTAP17-1, and KRT33A. Each is linked with FRMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD1-to-partner and partner-to-FRMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205C grouped by FRMD1-low versus FRMD1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD1→partner) and Y-score (partner→FRMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM205C →	+0.088	+5.029	<.001	.006	3	2
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRT33A →	+0.058	+4.930	<.001	.008	3	1
LUNG_SCLC	TRIM64B →	+0.066	+5.029	<.001	.006	3	1
LUNG_SCLC	OR2L8 →	+0.155	+5.029	<.001	.006	3	1
SKIN	KRTAP6-1 →	+0.060	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FAM205C by FRMD1 expression — LUNG_SCLC

Explore this box plot interactively →