FRK

Across TCGA cell cohorts, FRK mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRK-associated genes across cancer lineages are MCHR2, RIT2, and SLC35G3. Each is linked with FRK in more than 1 cancer types. Because this analysis shows association rather than direction, both FRK-to-partner and partner-to-FRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by FRK-low versus FRK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRK→partner) and Y-score (partner→FRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCHR2 →	+0.035	+4.684	<.001	.002	3	1
LARGE_INTESTINE	RIT2 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SLC35G3 →	+0.006	+4.467	.007	.004	3	1
LARGE_INTESTINE	KCNG4 →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.036	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MCHR2 by FRK expression — LARGE_INTESTINE

Explore this box plot interactively →