FRG2C

Across TCGA patient cohorts, FRG2C mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG2C-associated genes across cancer lineages are NAP1L4P2, MIR132, and RNU1-138P. Each is linked with FRG2C in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2C-to-partner and partner-to-FRG2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAP1L4P2 grouped by FRG2C-low versus FRG2C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2C→partner) and Y-score (partner→FRG2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAP1L4P2 →	+0.406	+4.268	<.001	.008	3	2
UCEC	MIR132 →	+0.353	+3.312	<.001	.001	3	2
LUSC	RNU1-138P →	+0.605	+3.687	.002	.004	3	2
SKCM	RNA5SP476 →	+0.133	+3.990	<.001	.009	3	2
SKCM	RN7SKP65 →	+0.096	+3.362	<.001	.006	3	2
BRCA	MIR6842 →	+0.551	+5.646	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

NAP1L4P2 by FRG2C expression — LUAD

Explore this box plot interactively →