Across TCGA cell cohorts, FRG2B mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRG2B-associated genes across cancer lineages are Savolitinib, Zibotentan, and Selisistat. Each is linked with FRG2B in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2B-to-partner and partner-to-FRG2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2B→partner) and Y-score (partner→FRG2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Savolitinib →	+0.366	+2.678	.041	.037	3	1
LARGE_INTESTINE	Zibotentan →	+0.242	+2.652	.016	.045	3	1
LARGE_INTESTINE	Selisistat →	+0.219	+2.652	.028	.045	3	1
LARGE_INTESTINE	GSK2801 →	+0.318	+2.649	.046	.046	2	1
LARGE_INTESTINE	123829 →	+0.671	+2.649	.020	.046	2	1
LARGE_INTESTINE	KIN001-236 →	+0.286	+2.652	.048	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

FRG2B survival (RNA) · tumor vs normal (RNA) · all FRG2B data types