FRG1HP

Across TCGA patient cohorts, FRG1HP mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG1HP-associated genes across cancer lineages are MIR412, USP9YP2, and H2AB3. Each is linked with FRG1HP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG1HP-to-partner and partner-to-FRG1HP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR412 grouped by FRG1HP-low versus FRG1HP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1HP→partner) and Y-score (partner→FRG1HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR412 →	+0.621	+8.066	<.001	.007	3	1
UCEC	USP9YP2 →	+0.054	+8.066	<.001	.007	3	1
SKCM	H2AB3 →	+0.079	+7.816	<.001	.008	3	1
UCEC	MIR4476 →	+0.736	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MIR412 by FRG1HP expression — UCEC

Explore this box plot interactively →