FRG1BP

Across TCGA patient cohorts, FRG1BP mutation is significantly associated with the RNA expression of many other genes, with 329 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG1BP-associated genes across cancer lineages are IFNA1, IFNA11P, and LINC01995. Each is linked with FRG1BP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG1BP-to-partner and partner-to-FRG1BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA1 grouped by FRG1BP-low versus FRG1BP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1BP→partner) and Y-score (partner→FRG1BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFNA1 →	+0.290	+4.681	<.001	.003	3	1
COAD	IFNA11P →	+0.268	+5.003	<.001	.004	3	1
COAD	LINC01995 →	+0.250	+5.003	<.001	.004	3	1
COAD	MIR6777 →	+1.148	+4.354	.003	.007	3	1
HNSC	TTTY2 →	+0.014	+7.954	<.001	.008	3	1
UCEC	CASTOR2 →	+1.124	+3.191	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 329 associations by consensus.

IFNA1 by FRG1BP expression — COAD

Explore this box plot interactively →