FRG1BP

Across TCGA pan-cancer cohorts, FRG1BP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FRG1BP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FRG1BP RNA is repressed in tumor relative to normal tissue. In most cancer types FRG1BP is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and KIRC are the cancer types where FRG1BP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRG1BP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.152	<.001	7	view →
UCEC	All	All	−1.581	<.001	6	view →
KIRC	All	II,III,IV	−0.458	.002	6	view →
CHOL	Female	All	+2.436	<.001	5	view →
COAD	Female	II,III,IV	−1.664	<.001	5	view →
LIHC	All	All	+0.834	<.001	5	view →
BRCA	Female	All	−0.334	.011	4	view →
KIRP	Female	II,III,IV	+0.893	.048	2	view →
READ	Female	All	−1.308	.047	1	view →
KICH	Male	II,III,IV	−1.096	.047	1	view →
BLCA	Male	IV	−0.535	<.001	1	view →
KIRP	Male	All	−0.421	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

FRG1BP–THCA

Open the THCA breakdown →