FRG1BP

Across TCGA patient cohorts, FRG1BP mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG1BP-associated genes across cancer lineages are ASNS, FoxM1, and S6_pS240_S244. Each is linked with FRG1BP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG1BP-to-partner and partner-to-FRG1BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FRG1BP-low versus FRG1BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1BP→partner) and Y-score (partner→FRG1BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.431	+3.000	.017	.036	3	2
UCEC	FoxM1 →	+0.285	+2.817	.028	.036	3	1
UCEC	S6_pS240_S244 →	+0.453	+3.000	.026	.036	3	1
UCEC	Tuberin →	+0.369	+2.179	.006	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.684	+2.827	.021	.035	3	1
UCEC	14-3-3_beta →	-0.160	-2.308	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by FRG1BP expression — UCEC

Explore this box plot interactively →