FRG1BP

Across TCGA cell cohorts, FRG1BP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FRG1BP-associated genes across cancer lineages are GUCA2A, IQCF5, and PPY. Each is linked with FRG1BP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG1BP-to-partner and partner-to-FRG1BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by FRG1BP-low versus FRG1BP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1BP→partner) and Y-score (partner→FRG1BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GUCA2A →	+0.058	+5.321	<.001	.005	3	1
CNS	IQCF5 →	+0.052	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	PPY →	+0.056	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	SPAG11A →	+0.104	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.020	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	KRTAP1-3 →	+0.050	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GUCA2A by FRG1BP expression — CNS

Explore this box plot interactively →