FRG1-DT

Across TCGA pan-cancer cohorts, FRG1-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FRG1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FRG1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types FRG1-DT is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where FRG1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRG1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.443	<.001	11	view →
THCA	Male	All	−0.562	<.001	10	view →
KICH	Male	All	−0.773	<.001	8	view →
BRCA	All	II,III,IV	−0.657	<.001	6	view →
LIHC	All	All	+0.080	.001	6	view →
CHOL	All	All	+0.224	<.001	3	view →
KIRP	Male	All	−0.293	.005	2	view →
HNSC	All	All	+0.096	.025	2	view →
ESCA	Female	All	−0.193	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FRG1-DT–KIRC

Open the KIRC breakdown →