Across TCGA cell cohorts, FREM3 mutation is significantly associated with the mutation status of many other genes, with 3,447 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FREM3-associated genes across cancer lineages are RTL1, NRCAM, and CELSR1. Each is linked with FREM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FREM3-to-partner and partner-to-FREM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM3→partner) and Y-score (partner→FREM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RTL1 →	+2.870	+3.129	.001	.001	1	5
SKIN	NRCAM →	+2.811	+2.811	.005	.005	1	4
LUNG_SCLC	CELSR1 →	+3.184	+2.714	.001	.001	1	4
CNS	SYNPO2 →	+4.459	+5.277	.005	.005	1	4
LUNG_NSCLC_LUAD	FERD3L →	+3.478	+3.303	.006	.006	1	4
LARGE_INTESTINE	BCR →	+2.728	+2.597	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,447 associations by consensus.

Exploration

FREM3 survival (RNA) · tumor vs normal (RNA) · all FREM3 data types