Across TCGA pan-cancer cohorts, FREM2-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FREM2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FREM2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FREM2-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, LUSC, and KIRC are the cancer types where FREM2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FREM2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.070	.002	6	view →
LUSC	Male	All	+0.110	.002	3	view →
KIRC	Female	All	+0.103	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FREM2-AS1 RNA expression & survival · all FREM2-AS1 data types