FRAT1

Across TCGA patient cohorts, FRAT1 mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRAT1-associated genes across cancer lineages are TRGJP1, RNU6-519P, and PRAMEF13. Each is linked with FRAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRAT1-to-partner and partner-to-FRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP1 grouped by FRAT1-low versus FRAT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAT1→partner) and Y-score (partner→FRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRGJP1 →	+0.593	+3.584	.003	.002	3	2
COAD	RNU6-519P →	+0.559	+3.541	.001	.002	3	2
UCEC	PRAMEF13 →	+0.045	+3.868	<.001	<.001	3	2
UCEC	MIR147A →	+0.163	+3.466	<.001	.003	3	2
UCEC	SETP4 →	+0.147	+2.408	<.001	.001	3	2
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

TRGJP1 by FRAT1 expression — COAD

Explore this box plot interactively →