FRAT1

Across TCGA pan-cancer cohorts, FRAT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FRAT1 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FRAT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FRAT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and UCEC are the cancer types where FRAT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.802	0.701	<.001	147	view →
SCLC	DFS	Median	III,IV	0.732	0.332	<.001	90	view →
UCEC	DFS	Median	IV	0.710	0.248	.001	62	view →
CESC	DFS	Tertile	All	0.814	0.623	<.001	60	view →
BRCA	OS	Tertile	All	0.976	0.940	.001	53	view →
LGG	OS	Median	All	0.876	0.736	<.001	45	view →
PAAD	DFS	Tertile	II,III,IV	0.348	0.228	.005	39	view →
KIRC	DFS	Quartile	All	0.903	0.695	.004	38	view →
OV	OS	Median	II,III,IV	0.644	0.733	.008	26	view →
ACC	DFS	Tertile	All	0.309	0.783	<.001	25	view →
UVM	OS	Median	II,III,IV	0.882	0.538	.002	24	view →
LIHC	DFS	Tertile	II,III,IV	0.245	0.519	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FRAT1–HNSC (OS)

Open the HNSC breakdown →