FRAT1

Across TCGA cell cohorts, FRAT1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRAT1-associated genes across cancer lineages are TTLL8, OR2D3, and CCDC73. Each is linked with FRAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRAT1-to-partner and partner-to-FRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by FRAT1-low versus FRAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAT1→partner) and Y-score (partner→FRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+2.925	<.001	.007	3	1
LARGE_INTESTINE	CCDC73 →	+0.043	+3.520	.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TTLL8 by FRAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →