FRA10AC1

Across TCGA cell cohorts, FRA10AC1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRA10AC1-associated genes across cancer lineages are TTLL8, TBC1D21, and TEX53. Each is linked with FRA10AC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRA10AC1-to-partner and partner-to-FRA10AC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by FRA10AC1-low versus FRA10AC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRA10AC1→partner) and Y-score (partner→FRA10AC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TEX53 →	+0.091	+4.684	.002	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
SKIN	OR6N1 →	+0.271	+5.415	<.001	.004	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TTLL8 by FRA10AC1 expression — LARGE_INTESTINE

Explore this box plot interactively →