FRA10AC1

Across TCGA pan-cancer cohorts, FRA10AC1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FRA10AC1 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FRA10AC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FRA10AC1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

ACC, BRCA, and UVM are the cancer types where FRA10AC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.426	0.842	<.001	91	view →
BRCA	OS	Median	III,IV	0.895	0.763	.001	67	view →
UVM	OS	Median	III,IV	0.386	0.905	.001	55	view →
SKCM	OS	Median	All	0.394	0.272	<.001	55	view →
LGG	OS	Median	All	0.543	0.348	<.001	54	view →
LIHC	DFS	Tertile	All	0.430	0.614	<.001	50	view →
KIRC	DFS	Tertile	All	0.906	0.773	.005	46	view →
LUSC	OS	Median	All	0.731	0.615	<.001	26	view →
UCS	DFS	Tertile	IV	0.996	0.594	.036	24	view →
CESC	OS	Median	III,IV	0.208	0.586	.008	22	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	15	view →
HNSC	OS	Median	All	0.601	0.796	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FRA10AC1–ACC (OS)

Open the ACC breakdown →