FPR2

Across TCGA patient cohorts, FPR2 mutation is significantly associated with the RNA expression of many other genes, with 1,392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPR2-associated genes across cancer lineages are NDUFAF5, MRPL39, and ZCCHC4. Each is linked with FPR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FPR2-to-partner and partner-to-FPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by FPR2-low versus FPR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPR2→partner) and Y-score (partner→FPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.321	+2.168	.002	.009	3	4
UCEC	MRPL39 →	+0.367	+2.024	.005	.005	3	3
UCEC	ZCCHC4 →	+0.413	+3.742	<.001	<.001	3	3
UCEC	SVIP →	+0.606	+1.947	<.001	.003	3	3
SKCM	MYLK-AS1 →	+0.402	+2.725	.006	.002	3	3
SKCM	UBE2I →	+0.263	+2.153	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,392 associations by consensus.

NDUFAF5 by FPR2 expression — UCEC

Explore this box plot interactively →