FOXS1

Across TCGA patient cohorts, FOXS1 mutation is significantly associated with the RNA expression of many other genes, with 500 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXS1-associated genes across cancer lineages are RNU6-376P, MIR6077, and PRSS53. Each is linked with FOXS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXS1-to-partner and partner-to-FOXS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-376P grouped by FOXS1-low versus FOXS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXS1→partner) and Y-score (partner→FOXS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-376P →	+0.283	+3.338	<.001	.004	3	3
LIHC	MIR6077 →	+0.469	+5.447	<.001	.005	3	2
UCEC	PRSS53 →	+0.382	+3.544	<.001	.002	3	2
UCEC	CDT1 →	+0.698	+3.483	.006	.002	3	2
UCEC	WDR76 →	+0.780	+3.375	.001	.004	3	2
LIHC	RN7SL66P →	+0.178	+5.758	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

RNU6-376P by FOXS1 expression — UCEC

Explore this box plot interactively →