FOXRED2

Across TCGA pan-cancer cohorts, FOXRED2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FOXRED2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FOXRED2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FOXRED2 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and HNSC are the cancer types where FOXRED2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXRED2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.273	<.001	3	view →
CCRCC	Male	III,IV	−0.508	.031	2	view →
HNSC	All	All	−0.272	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FOXRED2–LUAD

Open the LUAD breakdown →