FOXRED2

Across TCGA pan-cancer cohorts, FOXRED2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FOXRED2 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher FOXRED2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FOXRED2 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

CESC, LUSC, and ACC are the cancer types where FOXRED2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.933	0.809	<.001	86	view →
LUSC	OS	Median	All	0.829	0.690	<.001	74	view →
ACC	DFS	Tertile	All	0.269	0.711	<.001	68	view →
HNSC	DFS	Tertile	IV	0.713	0.501	<.001	57	view →
SKCM	OS	Median	All	0.735	0.830	<.001	51	view →
MESO	OS	Quartile	All	0.266	0.463	.003	51	view →
THCA	DFS	Tertile	IV	0.520	1.000	.003	44	view →
KICH	OS	Median	All	0.822	1.000	.008	39	view →
READ	DFS	Quartile	II,III,IV	0.916	0.346	.009	39	view →
LIHC	OS	Tertile	All	0.680	0.835	.001	34	view →
UVM	DFS	Tertile	All	0.444	0.695	.008	26	view →
BRCA	DFS	Tertile	IV	0.937	0.269	.002	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FOXRED2–CESC (OS)

Open the CESC breakdown →