FOXR1

Across TCGA patient cohorts, FOXR1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXR1-associated genes across cancer lineages are TSC1, eEF2, and EGFR_pY1068. Each is linked with FOXR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXR1-to-partner and partner-to-FOXR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by FOXR1-low versus FOXR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXR1→partner) and Y-score (partner→FOXR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSC1 →	-0.207	-2.321	.016	.035	3	2
UCEC	eEF2 →	+0.511	+2.321	.004	.035	3	1
UCEC	EGFR_pY1068 →	-0.367	-3.459	.003	.005	3	1
UCEC	GAPDH →	+0.579	+2.321	.031	.035	3	1
UCEC	INPP4B →	-0.368	-2.999	.023	.035	3	1
UCEC	p62 Lck ligand →	+0.384	+2.179	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TSC1 by FOXR1 expression — UCEC

Explore this box plot interactively →