FOXP3

Across TCGA patient cohorts, FOXP3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,418 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FOXP3-associated genes across cancer lineages are KLHDC7B, TTC24, and PDCD1. Each is linked with FOXP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP3-to-partner and partner-to-FOXP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXP3 versus KLHDC7B in BRCA, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP3→partner) and Y-score (partner→FOXP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLHDC7B →	+1.920	+0.740	.003	.002	3	2
HNSC	TTC24 →	+0.922	+0.617	.006	.003	3	2
HNSC	PDCD1 →	+1.483	+0.480	<.001	.006	3	2
HNSC	TRBV5-6 →	+1.066	+0.483	.002	.003	3	2
BRCA	TRAV26-1 →	+0.821	+0.445	.002	.005	3	2
HNSC	CRYGS →	-0.642	-0.447	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

FOXP3 vs KLHDC7B — BRCA

Explore this scatter interactively →