FOXO6-AS1

Across TCGA pan-cancer cohorts, FOXO6-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FOXO6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FOXO6-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXO6-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and HNSC are the cancer types where FOXO6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXO6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.162	<.001	9	view →
KICH	Male	All	−0.602	<.001	8	view →
HNSC	All	II,III,IV	+0.179	.001	8	view →
LIHC	All	All	+0.281	.001	7	view →
UCEC	All	III,IV	−1.096	<.001	6	view →
KIRP	All	III,IV	−0.253	.026	4	view →
CHOL	All	All	+1.372	<.001	3	view →
KIRC	All	All	+0.168	.015	2	view →
BLCA	Male	IV	−0.752	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FOXO6-AS1–THCA

Open the THCA breakdown →