Across TCGA patient cohorts, FOXO4 mutation is significantly associated with the RNA expression of many other genes, with 3,683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXO4-associated genes across cancer lineages are RPL17P14, FAM27B, and YTHDF3-AS1. Each is linked with FOXO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXO4-to-partner and partner-to-FOXO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO4→partner) and Y-score (partner→FOXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL17P14 →	+0.061	+4.884	<.001	.004	3	3
BRCA	FAM27B →	+0.086	+4.453	<.001	.005	3	2
UCEC	YTHDF3-AS1 →	+0.657	+2.024	<.001	<.001	3	2
UCEC	CCL5 →	+0.917	+2.662	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.673	+1.393	<.001	.005	3	2
UCEC	TRAC →	+0.766	+2.321	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,683 associations by consensus.

Exploration

FOXO4 survival (RNA) · tumor vs normal (RNA) · all FOXO4 data types