Across TCGA patient cohorts, FOXO4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXO4-associated genes across cancer lineages are PDCD4, STAT3_pY705, and Ku80. Each is linked with FOXO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXO4-to-partner and partner-to-FOXO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO4→partner) and Y-score (partner→FOXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.527	-1.643	<.001	.003	3	3
UCEC	STAT3_pY705 →	-0.339	-1.415	<.001	.010	3	3
UCEC	Ku80 →	+0.178	+1.594	.015	.021	3	2
UCEC	XBP1 →	-0.106	-1.794	.015	.024	3	2
UCEC	ASNS →	+0.328	+1.906	.003	.014	3	2
UCEC	BRCA2 →	-0.102	-1.896	.012	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

FOXO4 survival (RNA) · tumor vs normal (RNA) · all FOXO4 data types