FOXO3

Across TCGA cell cohorts, FOXO3 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXO3-associated genes across cancer lineages are GP2, CA5A, and GRIFIN. Each is linked with FOXO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXO3-to-partner and partner-to-FOXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP2 grouped by FOXO3-low versus FOXO3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO3→partner) and Y-score (partner→FOXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GP2 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
BREAST	GRIFIN →	+0.098	+4.199	<.001	.007	3	1
OVARY	BMP15 →	+0.123	+5.807	<.001	.001	3	1
OVARY	PDHA2 →	+0.006	+5.807	<.001	.001	3	1
OVARY	OR8B12 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

GP2 by FOXO3 expression — URINARY_TRACT

Explore this box plot interactively →