FOXN4

Across TCGA patient cohorts, FOXN4 mutation is significantly associated with the RNA expression of many other genes, with 1,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN4-associated genes across cancer lineages are FTHL17, RNU4-13P, and HMGB1P50. Each is linked with FOXN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN4-to-partner and partner-to-FOXN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by FOXN4-low versus FOXN4-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN4→partner) and Y-score (partner→FOXN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	FTHL17 →	+0.792	+4.847	<.001	.009	3	2
CESC	RNU4-13P →	+0.210	+6.584	<.001	<.001	3	2
UCEC	HMGB1P50 →	+0.162	+1.954	<.001	.004	3	2
UCEC	RN7SL248P →	+0.063	+3.307	<.001	.003	3	2
LUAD	SPATA42 →	+0.178	+3.811	.005	.002	3	2
LUAD	LINC02103 →	+0.176	+4.061	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,275 associations by consensus.

FTHL17 by FOXN4 expression — SCLC

Explore this box plot interactively →