FOXN3

Across TCGA patient cohorts, FOXN3 mutation is significantly associated with the RNA expression of many other genes, with 2,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN3-associated genes across cancer lineages are GRM7-AS2, CYCSP22, and COX6CP5. Each is linked with FOXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN3-to-partner and partner-to-FOXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM7-AS2 grouped by FOXN3-low versus FOXN3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN3→partner) and Y-score (partner→FOXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GRM7-AS2 →	+0.602	+4.369	<.001	.002	3	2
ESCA	CYCSP22 →	+0.107	+4.392	<.001	.006	3	2
ESCA	COX6CP5 →	+0.550	+4.159	<.001	.009	3	2
ESCA	APOOP3 →	+0.157	+4.967	<.001	.002	3	2
CESC	SNORD105B →	+0.498	+3.874	<.001	.006	3	2
LUSC	RNA5SP418 →	+0.574	+4.393	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

GRM7-AS2 by FOXN3 expression — BLCA

Explore this box plot interactively →