FOXN3-AS2

Across TCGA pan-cancer cohorts, FOXN3-AS2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated FOXN3-AS2 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FOXN3-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FOXN3-AS2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

UCS, BLCA, and SKCM are the cancer types where FOXN3-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.152	0.461	.003	72	view →
BLCA	DFS	Tertile	II,III,IV	0.725	0.488	.015	69	view →
SKCM	OS	Tertile	All	0.955	0.769	.010	51	view →
HNSC	OS	Tertile	II,III,IV	0.325	0.624	.011	36	view →
THCA	OS	Tertile	III,IV	0.508	0.810	.009	21	view →
CESC	DFS	Tertile	All	0.890	0.804	.023	18	view →
ESCA	OS	Tertile	IV	0.243	0.738	.024	18	view →
COAD	DFS	Tertile	III,IV	0.390	0.707	.023	18	view →
KICH	DFS	Quartile	II,III,IV	0.251	0.842	<.001	13	view →
KIRC	OS	Quartile	All	0.501	0.671	.005	13	view →
MESO	OS	Tertile	II,III,IV	0.756	0.523	.031	12	view →
PAAD	OS	Tertile	II,III,IV	0.249	0.426	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

FOXN3-AS2–UCS (DFS)

Open the UCS breakdown →