FOXN3-AS1

Across TCGA pan-cancer cohorts, FOXN3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FOXN3-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FOXN3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FOXN3-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

LGG, LAML, and HNSC are the cancer types where FOXN3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.726	0.869	<.001	32	view →
LAML	DFS	Tertile	All	0.453	0.686	.004	26	view →
HNSC	OS	Quartile	IV	0.210	0.462	.005	26	view →
COAD	DFS	Quartile	III,IV	0.228	0.592	.007	22	view →
KIRC	DFS	Median	All	0.713	0.529	.003	21	view →
BLCA	DFS	Quartile	IV	0.144	0.540	.016	21	view →
KIRP	DFS	Median	II,III,IV	0.847	0.176	.004	18	view →
LUSC	OS	Quartile	All	0.841	0.686	.007	14	view →
OV	OS	Tertile	All	0.908	0.793	.019	14	view →
THYM	OS	Median	All	0.749	1.000	.010	13	view →
BRCA	OS	Quartile	All	0.960	0.905	.009	13	view →
THCA	DFS	Tertile	IV	1.000	0.470	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FOXN3-AS1–LGG (OS)

Open the LGG breakdown →