FOXN3-AS1

Across TCGA pan-cancer cohorts, FOXN3-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FOXN3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOXN3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXN3-AS1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where FOXN3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXN3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+0.824	<.001	9	view →
LIHC	Male	All	+0.869	<.001	6	view →
BRCA	Female	II,III,IV	−0.658	<.001	6	view →
KICH	Female	All	+1.096	<.001	5	view →
LUSC	Female	All	+1.028	<.001	5	view →
BLCA	Male	IV	−0.962	.002	2	view →
PAAD	Male	All	−0.810	.014	2	view →
STAD	Male	All	−0.411	.018	2	view →
PRAD	All	All	+0.381	<.001	2	view →
THCA	All	All	−0.216	.019	2	view →
READ	All	II,III,IV	−1.167	.022	1	view →
BLCA	Female	IV	+0.710	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

FOXN3-AS1–KIRC

Open the KIRC breakdown →