FOXN2

Across TCGA patient cohorts, FOXN2 mutation is significantly associated with the RNA expression of many other genes, with 3,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN2-associated genes across cancer lineages are EIF3M, EI24, and CENPU. Each is linked with FOXN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXN2-to-partner and partner-to-FOXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3M grouped by FOXN2-low versus FOXN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN2→partner) and Y-score (partner→FOXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3M →	+0.376	+2.648	.005	<.001	3	2
UCEC	EI24 →	+0.478	+3.949	<.001	<.001	3	2
UCEC	CENPU →	+0.831	+3.839	<.001	<.001	3	2
UCEC	OBI1 →	+0.400	+2.255	.003	.001	3	2
UCEC	PELO →	+0.386	+3.628	.002	.001	3	2
UCEC	CFDP1 →	+0.524	+2.346	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,735 associations by consensus.

EIF3M by FOXN2 expression — UCEC

Explore this box plot interactively →