FOXN2

Across TCGA pan-cancer cohorts, FOXN2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FOXN2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FOXN2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXN2 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where FOXN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.541	<.001	12	view →
KIRC	Male	All	+0.543	<.001	10	view →
STAD	All	II,III,IV	+1.037	<.001	8	view →
COAD	Male	All	+0.755	<.001	6	view →
BRCA	All	III,IV	−0.701	<.001	6	view →
LIHC	Male	All	+0.900	<.001	5	view →
KICH	Female	All	−1.219	<.001	4	view →
ESCA	All	All	+1.141	.003	2	view →
LUAD	Female	II,III,IV	−0.568	<.001	2	view →
THCA	All	All	−0.271	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FOXN2–HNSC

Open the HNSC breakdown →